Sodium hyaluronate for treatment of chondromalacia patella syndrome

doi:10.3969/j.issn.2095-4344.2014.52.029

Abstract

Abstract:

BACKGROUND: According to the special physical and chemical properties, the sodium hyaluronate plays a very important physiological role, such as constructing the cellular matrix, lubricating the joints, and promoting the repair of tissue damage.

OBJECTIVE: To observe the therapeutic effect of sodium hyaluronate on chondromalacia patellar syndrome with different disease courses.

METHODS: A total of 76 patients with chondromalacia patellar syndrome received intra-articular injection of 2 mL sodium hyaluronate once a week for 5 consecutive weeks as a course, with the entry point on the medial margin of the patella. All the patients were divided into two groups according to the disease course: < 3 months group (n=32) and > 3 months group (n=44). One-year follow-up was done to summarize the therapeutic effect.

RESULTS AND CONCLUSION: After follow-up for 1 year, the excellent and good rate was 94% in the < 3 months group, which was superior to the > 3 months group (73%). There was no side effect and infection during the treatment. Five patients appeared to have pain worsened after treatment, which may be caused as follows: Patellar effusion was removed incompletely and early puncture was unskilled. The pain was relieved within 1-2 days after the break. Results showed that the sodium hyaluronate is an effective drug for chondromalacia patellar syndrome, while early treatment and reasonable entry point is the key to keep the therapeutic effects.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: chondromalacia patellae, hyaluronic acid, injections, intra-Articular, treatment outcome

CLC Number:

R318

Yan Hao-ran, Cai Jun-feng, Shen Bin, Wen Jun-xiang, Tan Jun. Sodium hyaluronate for treatment of chondromalacia patella syndrome [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(52): 8525-8528.

Figures/Tables 1

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